How CBD interacts with other drugs?

Treating certain ailments with CBD is a relatively new phenomenon. There is still much to discover about the operation of the plant material on the body and how it responds to any other medications. Fortunately, we have Cassini  Steven -  a biochemist here to shed light and make clear to us how to deal with CBD when using certain medications.

Processing of drugs
Before a drug or natural substance disappearing from the body, it should often first be metabolized. The metabolism of drugs takes place in two phases: in Phase I, response, the drug is polar (water soluble) is made by oxidation, reduction or hydrolysis. And in Stage II, the drug is conjugated, for example, by acetylation or methylation.

This allows the water solubility and polarity of the drug are increased and can easily be excreted by the kidneys or gall. Metabolism of drugs takes place mainly in the liver, but other organs such as the skin, gastro-intestinal system, lungs, brains and kidneys may be involved.

The cytochrome P450 system
The cytochrome P450 enzyme system (also abbreviated as CYP, or P450 CYP450) is a collection of 57 enzymes. Of these, there are 15 important in the degradation of different (xenobiotic) substances such as drugs and toxins, but also in natural substances such as THC, and other cannabinoids . These enzymes are not only important in the metabolism of drugs, natural compounds and other foreign substances. But also play a role in physiological processes such as the oxidation of fatty acids.

The rate at which certain substances varies broken down per person. Therefore every body reacts differently to cannabinoid drugs

Some natural substances can inhibit the activity of a CYP enzyme, allowing the plasma concentrations of drugs - or other natural substances that are metabolized by this enzyme - rise.

The capacity of the P450 enzyme system differs per person. This means that not everyone at a particular dose of a drug or natural compound react the same. The rate at which a drug or natural substance extracted from the body is excreted is decisive for the serum concentration that arises in the body, which can in turn influence on the effect.


CBD can inhibit degradation drugs

CBD, the P450 enzymes responsible for inhibiting the breakdown of certain drugs. Through the inhibition of these enzymes the medication breaks down less well, and can increase the concentration of the particular drug in the blood.

This can be an advantage under controlled omstandigdheden, because you have less than needed for the same activity. However, it can include uncontrolled omstandigdheden be dangerous because it can ensure that the drug concentration is too high in the blood and thereby increases the risk of serious side effects.


CBD enhanced either weakening the effects of THC

CBD can thus increase the effect of certain drugs. When CBD is ingested before THC, CBD  reinforces the effects of THC. The THC is degraded P450 enzymes by the same group and thus the CBD inhibits the degradation of THC.

The CBD molecule may enhance both the psychoactive effects of THC and weaken depending on the sequence and timing of intake

However, when CBD is taken at least one hour after the intake of THC, CBD reduces the psychoactive effects of THC, CBD since then has anti-psychotic activity.

CBD and chemotherapy
Most cytotoxic drugs (chemotherapy) are also broken P450 enzymes by the same group. Since the fatal and therapeutic dose in certain cytostatics very close to each other, it is not wise to take high doses of CBD during chemotherapy because the concentration of cytotoxic drugs in the blood may rise dangerously high.

The terpene myrcene is also a potent inhibitor of the group of P450 enzymes. Some recreational users consume cannabis for smoking cannabis a mango. In the fruit is because a relatively high concentration of myrcene. Because myrcene selectively inhibits the P450, it ensures that it enhances the effects of THC.

CBD and drugs
In addition to the list below, there are many other drugs that are metabolised by the cytochrome P450 enzyme system. It is the use of such drugs always wise to ask the doctor or the medicine you use is changed or canceled by the group P450 enzymes.

List of medicines that interact with CBD:
·        Anticonvulsants
·        antidepressants
·        beta-blockers
·        antipsychotics
·        benzodiazepines
·        Statins
·        Blood thinners
·        steroids
·        NSAIDs
·        antibiotics

If this is the case then it is recommended to (particularly at high doses) carefully to deal with CBD supplements and the dosage of the drug - in consultation with the treating physician - possibly reducing monitored.

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